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Molecules administered by IN can reach the CSF and brain parenchyma within minutes of dosing, offering a rapid therapeutic onset, which might be beneficial in acute settings, including acute brain injuries or stroke

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Durand et al, 1996b, 1997a

If you experience significant side effects at any dose, you can remain at that dose for 6-8 weeks before escalating, or temporarily step back to the previous dose

Research continues with other GLP-1 agents and in different patient populations