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However, combining them requires careful medical supervision due to overlapping effects on weight and appetite, plus potential side effects that may be amplified
Defects in SDH subunits lead to succinate accumulation and oncometabolite-driven pseudohypoxia and are strongly linked to hereditary paragangliomas, pheochromocytomas and certain renal cell carcinomas, underscoring the essential role of complex II in metabolic and redox homeostasis 78,79
Long-term, prospective studies are still needed, Hardaway said
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