doi: 10.3748/wjg.v20.i47.17756 67
It currently makes three drugs that contain semaglutide, including: Wegovy, a once-weekly injectable medicine for weight loss and cardiovascular risk reduction Ozempic, a once-weekly injectable medicine for Type 2 diabetes and cardiovascular risk reduction, often prescribed off-label (for a non-FDA-approved use) for weight loss Rybelsus, a daily oral medicine for managing blood sugar levels in people with Type 2 diabetes, and sometimes prescribed off-label for weight loss These three brand-name medicines are the only FDA-approved semaglutide products
However, significant gaps in research, including inconsistent methodologies, small sample sizes, and limited data on long-term effects, necessitate further robust clinical trials
What are the 4 Main GLP-1 Drugs
Here is what participants achieved on average: Mounjaro (tirzepatide 15mg) SURMOUNT-1: Week 4: approximately 2 to 3% body weight loss Week 12: approximately 7 to 8% Week 24: approximately 13 to 15% Week 52: approximately 18 to 20% Week 72 (end of trial): average 20.9% Wegovy (semaglutide 2.4mg) STEP 1: Week 4: approximately 1 to 2% body weight loss Week 12: approximately 5 to 6% Week 24: approximately 9 to 10% Week 52: approximately 12 to 14% Week 68 (end of trial): average 14.9% These are averages