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da Cunha AA, Ferreira AG, Loureiro SO, da Cunha MJ, Schmitz F, Netto CA, Wyse AT (2012) Chronic hyperhomocysteinemia increases inflammatory markers in hippocampus and serum of rats

This randomized, double-blind, placebo-controlled trial in 58 older adults identified as "pre-frail" found an decrease in a Frailty Index score and an improvement in the hand grip test in individuals supplemented with L-carnitine (1.5 g/day) over 10 weeks but not in those given a placebo (118)