A phase 3, double-blind, randomized, placebo-controlled trial was conducted across seven countries
Pharmacokinetic parameters, time to reach the maximum concentration (T max ), clearance rectified by bioavailability (CL z/F ), mean resident time (MRT), including area under the plasma concentration-time curve (AUC), elimination half-life (T 1/2 ), apparent volume of distribution rectified by bioavailability (V z/F ) were analyzed by a non-compartmental method using Winnonlin 8.10 software (Pharsight Co., United States) software
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