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Check pregnancy status before starting and avoid during pregnancy
In the brain, semaglutide acts on appetite centers to: Reduce hunger Slow eating Increase feelings of fullness It also delays gastric emptying so food stays in the stomach longer, which helps reduce meal size
In people with type 2 diabetes, this directly helps lower blood sugar levels, but in people without diabetes, their blood sugar levels remain in the normal range
Fast or recent weight loss can impact nutrition and wound healing
Both classes are highly effective in reducing cardiovascular events in patients with type 2 diabetes across the spectrum of CVD risk (notably, our prior work comparing across mediation classes suggests that SGLT2is may be even more favorable than GLP-1RAs for some outcomes, and are comparable on others), and we assume that taking both together is likely to be even more beneficial
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