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Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

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Cell 175 , 69 (2018)

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Presumably, the tissue that you focus the light on, if it's a focused light, is going to derive the greatest benefit, right