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McIntyre et al., 2024)

Two small trials in type 1 diabetes patients a decade ago suggested that the combination of insulin treatment and a GLP-1-RA could cause potentially severe low blood sugar levels (hypoglycemia), and reducing insulin to minimize this risk could cause a different serious complication called diabetic ketoacidosis

Senior citizens, who are the most at risk for zoster, have substantial risk of postherpetic neuralgia lasting over a year, and sometimes for the rest of their lives. If you have a lot of pain before the rash, it puts you at much higher risk for postherpetic neuralgia, adds Joseph Safdieh, MD, professor of neurology at Weill Cornell Medicine in New York City

The SUSTAIN and PIONEER trial series highlighted not only its effectiveness in these areas but also its cardiovascular safety profile, making it a suitable option for a broad spectrum of patients, including those with a high risk of cardiovascular events