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Weight loss was dose-related between retatrutide doses of 1 to 8mg

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and 0.33g of the compound 1 was dissolved in 100mL of acetonitrile, and then added dropwise to the above mixture to react at 0 to 5 for 3 hours, the resulting reaction solution was adjusted to pH 5.0 with trifluoroacetic acid, and then 2 times of purified water was added thereto, and centrifugation was carried out to obtain a solid compound 2, the liquid chromatogram of FIG