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Every patient starts with a full metabolic and cardiovascular baseline, a dose escalation schedule built around their specific physiology, and active monitoring throughout so that side effects get caught and managed before they become problems rather than after
One potential issue associated with high doses of folic acid is that it has a masking effect on the diagnosis of pernicious anaemia due to vitamin B 12 deficiency, and may even precipitate or exacerbate neuropathy in vitamin B12-deficient individuals
In total, 1,606 participants, who were on average male and of 58.2 years of age, participated in the phase three program for regulatory approval
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