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Short-acting GLP-1RAs slow down stomach emptying more than long-acting ones [2]
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However, these results must be contextualised carefully: Phase 2 trials are not powered to detect cardiovascular outcomes such as myocardial infarction, stroke, or cardiovascular mortality No dedicated cardiovascular outcome trial (CVOT) data exist for retatrutide such trials are required before definitive conclusions about cardiovascular benefit or risk can be drawn
Messers take aligns with that of the surgeons I interviewed: Higher rates of surgical wound reopening and delayed healing [in GLP-1 patients] may be linked to the drugs impact on gastrointestinal motility [the way food, liquid, and waste move through the stomach] and nutrient absorption, potentially leading to nutritional deficiencies that impair wound healing, says the endocrinologist
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