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Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia
Dry eye syndrome or keratoconjunctivitis sicca is defined by the eyes failing to produce enough tears to properly lubricate or when tears that are produced evaporate too quickly
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The landmark Phase IIb clinical trial published in The Lancet (TIPO-1 study) evaluated 203 obese patients randomly assigned to receive tesofensine at doses of 0.25mg, 0.5mg, or 1.0mg daily for 24 weeks alongside an energy-restricted diet
SMD 0.24)
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