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Notable gastrointestinal side effects include: Constipation Diarrhea Abdominal pain Pancreatitis Gallbladder disease Despite side effects being found mainly in the stomach and intestines, gallstones and pancreatitis can result in perceived muscle aches and medication-related Ozempic back pain

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After ~13 months Dark spots and hyperpigmentation may begin to fade, and overall dullness can decrease

Excessive skin lightening: In some cases, glutathione may lighten skin more than intended - particularly with aggressive or prolonged dosing beyond what was planned

Biomarker qualification: evidentiary framework