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found in some OTC cosmetics Off-label use discussed here: wound healing (topical and injectable) Evidence level: preclinical strong, human clinical limited (GRADE equivalent: very low to low) Key mechanism: upregulates collagen I/III, VEGF, decorin, and anti-inflammatory cytokines Typical compounded concentration: 0.01% to 1% topical
eLife (2019)
Some peptide shops display third-party certificates authenticating the purity of specific batchesnot foolproof, but better than companies that dont test at all
However, berberine is not approved as a pharmaceutical drug in most countries and lacks the decades of safety and efficacy data that metformin carries
& De Marchis, S
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