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What the Research Suggests Clinical studies and pilot trials evaluating intralesional PRP for Peyronies disease have demonstrated: Favorable safety profiles Potential improvements in curvature and sexual function Reduced plaque density in some patients Some investigational protocols specifically include plaque needling prior to PRP injection , recognizing that mechanical disruption may enhance the effectiveness of regenerative therapies

However, outcomes depend heavily on dosage, treatment frequency, and patient metabolism

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PMCID: PMC6389332