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Quick comparison: the FDA letter is a reputational signal, not a safety signal
Second, it helps identify potential synergistic effects when multiple receptors are engaged simultaneously
Hypoglycemia (low blood sugar) is uncommon when these medications are used alone but may occur when combined with insulin or sulfonylureas
and a 44% decreased risk of death
Progression of such an anemia leads to a decreased oxygen carrying capacity of the blood and may ultimately result in symptoms of fatigue, weakness, and shortness of breath (1)
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