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In case a serious adverse event would require the randomization code to be broken for a given participant, sealed opaque envelopes labelled with the randomization number and containing the associated supplements were prepared by the same unblinded individual, and kept at the clinical center

This is legal and common in medicine but should be guided by evidence and shared decision-making

Phase 2 data showed participants losing up to 18.7% of body weight at the highest dose over 46 weeks

Side effects are rare but can include mild pain at the injection site, slight swelling, or bruising

39 Another study that compared intravenous, intrathecal, and intranasal administration of exosomes found that intranasal administration was best for delivery to the brain