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Fumarate, a naturally occurring compound in the body, serves as an intermediate in the Krebs cycle, a key energy-producing process that takes place in the mitochondrion

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Among them, Baicalein (including its precursor Baicalin) has been the most widely researched, demonstrating effective ferroptosis inhibition in various CNS injury models, including SAH-EBI, ICH, IS, CIRI, TBI, and TBI-PTE

80 demonstrated that this indole reduced LPS-induced inflammation and thus NLRP3 inflammasome formation in mouse adipose tissue by acting on the expression of inflammasome genes, including NLRP3, ASC, and thereby caspase-1 and IL-1