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ACT-AD Trial: Phase 2 Failure The ACT-AD phase 2 trial enrolled Alzheimer's patients and tested fosgonimeton efficacy on cognitive decline
The preclinical results are robust and the mechanistic rationale is strong, but caution is warranted until larger, controlled human trials are completed
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As an additional example to that of the trefoil peptides noted above, the peptide EGF (epidermal growth factor) is produced in human milk to promote growth of the gastrointestinal tract in newborn infants, but the same peptide aggressively stimulates the growth of breast cancer cells in adults
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