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In the early 2000s, more than 100 cases of liver toxicity related to the use of kava had been identified, some leading to liver transplant and some leading to death
the excess free radicals deplete glutathione reserves, and the decreased ATP production slows glutathione replenishment, ultimately resulting in chronic glutathione deficiency [8]
These effects are attributed to its ability to modulate fibrotic signaling pathways and reduce collagen deposition (Hamza 2010)
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