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Since the cytosol contains high concentrations of glutathione and is, therefore, a reducing environment, proteins containing disulfide bonds, which are formed from oxidized cysteine residues, cannot be produced within it

A child may have normal copper on standard lab ranges yet still have very high free copper , because the ceruloplasmin binding capacity is low

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Alessio HGA, Cao G: Exercise-induced oxidative stress before and after Vitamin C supplementation