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Gradual dosing does not delay results
High rates of attrition (12%) were observed in Altimmunes trials, and 5% of patients on semaglutide discontinued treatment due to nausea, vomiting or diarrhea (with 25-44% of patients reporting symptoms)
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MT-1s receptor selectivity also means it does not require the same aggressive dose titration as MT-2 the melanotan-1 dosage protocol escalates more quickly because off-target effects are less likely even at maintenance doses
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