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2 Arteriosclerosis obliterans ASO is a subtype of peripheral artery disease with increasing global incidence ( 2.1 Pathology of arteriosclerosis obliterans Formation of arterial plaques and subsequent vascular narrowing play crucial roles in ASO development ( 2.2 High-risk factors of arteriosclerosis obliterans Many risk factors, including smoking, age, sex, genetics, diabetes, hypertension, and hyperlipidemia, can lead to ASO, and these factors are often associated with lipid metabolism disorders and inflammation ( Smoking is a significant risk factor for vascular diseases, especially those affecting lipids and cytokines, which contribute to vascular damage and ASO