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A systematic review and meta-analysis of 11 randomized controlled trials involving 840 women with PCOS concluded that GLP-1RAs significantly improve natural conception rates (RR: 1.72, 95% CI: 1.222.43
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However, real-life analyses indicate a higher discontinuation rate, of approximately 70% stopping within 2 years, especially in non-diabetic patients (112, 113)
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