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These include anorectic effects driven by previously discussed central modulation of satiety and reward pathways and peripheral activation of vagal afferents, delayed gastric emptying, anti-inflammatory properties, potential impact on energy expenditure and the ability to reduce ghrelin levels, which are inherently elevated in PWS ( 2 to 11.3 kg/m 2 (3135), waist circumference reduction from 7 to 8 cm (32, 35), as well as HbA1c reduction from 1.9% to 6.5% (3134)

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2g), and similar results were apparent in the 16-h fast-refeed paradigm (Fig