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The authors systematically evaluated conflicting findings regarding DSIP's sleep-promoting effects, noting that while initial studies showed dramatic increases in slow-wave sleep, subsequent research produced more variable results depending on species, administration route, and baseline sleep states
A 2021 study reported motor-function recovery after focal stroke in rats (PMID 34500605), and 2018 work on phosphorylated DSIP reported restored spatial memory and improved sleep architecture in a high-altitude model (PMID 30107169)
In SURMOUNT-1, adults with obesity (without diabetes) lost an average of 15.0%, 19.5%, and 20.9% of body weight with tirzepatide 5 mg, 10 mg, and 15 mg respectively over 72 weeks, compared to 3.1% with placebo
These data are consistent with known differences in cell death signals activated across these three groups (cisplatin, acute aminoglycosides, and chronic aminoglycosides)
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