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RCTs that showed significant weight loss during treatment periods compared with the control group and studies that did not show significant weight loss were divided into two subgroups

Kakavand H, Crainic O, Lum T, O'Toole SA, Kefford RF, Thompson JF et al

When the drug levels fall during an extended dosing interval, food noise may return more strongly, which makes it harder to sustain healthy eating habits

Cardioprotective actions include the inhibition of TLR4/NF- B/NLRP3 signaling, reduction of cytokine levels (such as IL-6 and IL- 1), and prevention of myocardial remodeling and dysfunction

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