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ROS activates p38 and c-Jun N-terminal kinase (JNK), and subsequently interferes with insulin signaling by increasing serine phosphorylation of insulin receptor substrate 1 (IRS-1) at specific sites, ultimately leading to insulin resistance

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Full structural remodeling at 4 to 6 months of bi-weekly microinfusion sessions

Contraindications include active or recent cancer, uncontrolled diabetes, severe diabetic retinopathy, and pregnancy

Peptides, particularly immune-modulating peptides , can influence multiple pathways simultaneously