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In SUMMIT, tirzepatide reduced the composite of cardiovascular death or worsening heart-failure events by 38% (HR 0.62, 95% CI 0.410.95) and worsening HF events alone by 46% (HR 0.54, 95% CI 0.340.85), with a +6.9-point between-group improvement in the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS), an 18-meter improvement in 6-minute walk distance (6MWD), and a placebo-adjusted weight loss of 11.6% [5]

Since GLP-1s deliberately slow down digestion, they can make this problem much worse