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This mechanism relies on intact pituitary and hypothalamic function, making efficacy dependent on baseline hormonal reserve and individual receptor sensitivity
Effects of duration of diabetes on behavioural and cognitive parameters in streptozotocin-induced juvenile diabetic rats
NK cells antitumor activity also seems to depend on arginine levels, at least in an animal model based on human gastric cancer cells [91]
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Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)
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