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Moreover, the consistent use of phytochemicals such as polyphenols, flavonoids, and eugenol present in neem and clove may regulate cytokine profiles, modulate microbial flora and sustain epithelial integrity, thus optimizing the tissue environment in which the activity of vitamin D dependent pathways involved in immunoregulation and bone homeostasis can operate to its full potential ( 240 )
We found that LOsG did not alter the mRNA levels of ER-stress responsive genes Xbp1 and BIP, inflammation-responsive genes IL6 and IL1, and hypoxia-response genes HIF1 and GAPDH compared with sham control mice (Fig
These data represent evidence of the involvement of excessive levels of NO in the pathogenesis of ASD
The association between smoking and MASLD is underpinned by shared pathological mechanisms, particularly insulin resistance and visceral fat accumulation, which are central to the metabolic syndrome (MetS)
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