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The 12mg cohort achieved the highest mean body weight reduction at -24.2% exceeding all published results for semaglutide (approximately -16% in the STEP trials) and tirzepatide (approximately -22.5% in SURMOUNT-1) at their respective maximum doses

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Birth issues: The FDA recommends GLP-1s not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because animal studies demonstrate it may cause higher rates of miscarriage and birth defects