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Third, there was heterogeneity between the included trials, such as study design, the definition of confirmed hypoglycemia, dose titration strategy, and antidiabetic medication used at baseline
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Y4 receptors are widely distributed in peripheral tissues, particularly showing significant expression in the human small intestine, ileum, coronary arteries, and cardiac tissue (62)
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Given the chronic nature of type 2 diabetes and the challenges associated with weight management, tirzepatide has garnered significant attention due to its effectiveness in clinical trials
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