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Renal carnitine loss may also affect the morphology and function of red blood cells and reduce the oxygen carrying and releasing capacity of red blood cells, thereby reducing tissue oxygen supply (including the kidney), and tissue hypoxia activates hypoxia-inducible factor 1 (HIF-1), which in turn reduces OCTN2 expression through the HIF-1-PPAR signaling pathway

These treatments are particularly beneficial for those with a body mass index (BMI) of 30 or higher or individuals with a BMI of 27 or higher with comorbidities such as type 2 diabetes, high blood pressure, or high cholesterol

What about side effects?+ Nausea, reflux, and constipation are the most common early side effects and usually manageable with slow dose titration and lifestyle adjustments

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