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The model development was done using non-linear mixed-effect modeling (NONMEM, edition 7, ICON Development Solutions, Ellicott City, MD, USA)

8 Though companion animals, such as dogs and cats, make up a large percentage of compounded veterinary preparations, other species such as small mammals, birds, and lizards may also be in need of compounded treatment

DIRECTIONS FOR USE: Use GlutaMAX to wash face and body

Pre-Blend Reconstitution Math (12.5/2.5 mg, 15 mg total) Metric Blend composition Value 12.5 mg retatrutide + 2.5 mg cagrilintide Metric BAC water added Value 2.5 mL Metric Concentration Value 5.0 mg/mL retatrutide + 1.0 mg/mL cagrilintide Metric Ratio held constant Value 5:1 (reta : cag) What Each Draw Delivers (12.5/2.5 mg Pre-Blend) Draw Volume 0.20 mL Units 20 units Retatrutide 1.0 mg Cagrilintide 0.2 mg Draw Volume 0.40 mL Units 40 units Retatrutide 2.0 mg Cagrilintide 0.4 mg Draw Volume 0.60 mL Units 60 units Retatrutide 3.0 mg Cagrilintide 0.6 mg Draw Volume 0.80 mL Units 80 units Retatrutide 4.0 mg Cagrilintide 0.8 mg Draw Volume 1.20 mL Units 120 units* Retatrutide 6.0 mg Cagrilintide 1.2 mg Draw Volume 1.60 mL Units 160 units* Retatrutide 8.0 mg Cagrilintide 1.6 mg Draw Volume 2.40 mL Units 240 units* Retatrutide 12.0 mg Cagrilintide 2.4 mg * Volumes above 100 units exceed a standard 1 mL insulin syringe - split into two injections or use a larger syringe