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Acta 1830 (5), 32893303

have provided evidence that tofacitinib directly modulates mitochondrial function, such as regulating key mitochondrial genes, increasing oxidative phosphorylation, enhancing ATP production while diminishing glycolytic flow and key glycolytic genes (162)

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At the end of the treatment period, measurements of femur and tibia length were obtained by dissection of the surrounding muscle tissues and disarticulation without disturbing the articular cartilages, using an electronic digital calliper

Readers interested in how researchers think about combining compounds may find our overview of peptide stacking useful for understanding why such combinations require particular caution when the individual agents are themselves poorly characterized