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Sermorelin itself is not licensed for therapeutic use in the UK, whilst tirzepatide (Mounjaro) is only approved as monotherapy for type 2 diabetes and weight management

Essentially absent at GH-relevant concentrations

The tradeoff is that higher doses require substantial volumes, and a full 2.4mg maintenance dose would require nearly 1.44ml, which exceeds the capacity of a standard 1ml insulin syringe

The slow absorption is facilitated by the C18 fatty acid modification promoting local tissue interactions and self-association

The significant appetite suppression caused by tirzepatide often leads to reduced caloric intake, which is therapeutic for weight loss but may result in insufficient energy consumption for some patients