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Diethyl ether was added to precipitate the oligomer and the solid was triturated and filtrated

MiR-491-3p was shown to negatively regulate the expression of both IGFBP-2 and the cell cycle effector CDK6, whereas the other miR-491 product, miR-4915p targets EGFR and CDK6, leading to decreased cellular proliferation, invasion, and stem cell propagation [42]