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Emerging evidence suggests that ALC levels are reduced in individuals with MDD, and this deficiency may contribute to depressive symptoms through disruptions in mitochondrial fatty acid transport, neuroplasticity, and neurotransmission

It can be difficult to sort out hyperammonemia-induced seizure versus seizure-induced hyperammonemia

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10.1016/j.cmet.2016.07.010 Cell Metab

Every step in this chain is an opportunity for error or contamination