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Description

-Syn oligomers cause massive degeneration and loss of nigrostriatal dopaminergic neurons, in turn inducing PD through multiple mechanisms, involving mitochondrial dysfunction, endoplasmic reticulum stress, proteasomal influences, neuroglial cellular and inflammatory responses, membrane damage, synaptic dysfunction, autophagy and lysosomal dysfunction (Bengoa-Vergniory et al., 2017)

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Spinosogenesis was assessed by measuring spine numbers per 50-m dendritic length

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It is administered as a once-weekly subcutaneous injection and belongs to a novel class of medications known as dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists

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