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However, the term safe for most people does not imply safe for all situations, no questions asked

In practice with GHK-Cu: The copper dose delivered via typical topical or therapeutic administration is modest Short-term use has not been prominently associated with clinically significant zinc depletion Long-term or high-dose use warrants monitoring in patients where zinc balance is clinically important Patients with known zinc deficiency or on zinc-replacement should be monitored more closely A reasonable clinical approach: monitor copper and zinc status in patients on chronic GHK-Cu, particularly in symptomatic or long-duration protocols

however, GSH levels in the DLPFC were marginally higher in PTSD participants who tested positive for cannabis ( n = 10) on scan day ( p = 0.053, 25% higher), compared to those who tested negative ( n = 4)

Worsening mental health was assessed through data on psychiatric hospital admissions, sick leave from work due to mental health reasons, hospitalisation owing to self-harm and death by suicide