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Additionally, funds may now be used not only for external vendors but also to hire or train internal staff in areas such as market research, IP strategy, regulatory planning, and manufacturing

Theres no built-in safety margin like other substances

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The only problem is that B12 is not that easily found in food very few foods are B12-rich and they are essentially meat, eggs, and fermented foods

If a patient has those complications, then I would go straight to the GLP-1 based drug where the evidence there for improvement