Conversely, ACSL4 expression, along with levels of ROS, MDA, 4-HNE, Fe 2+ , and -synuclein, were markedly elevated, thereby exacerbating ferroptosis and lipid peroxidation in the brain
3 (C)) are in vivo confirmation of in vitro findings on the potential of creatine to remove reactive oxygen species ( Reference Lawler, Barnes and Wu 34 , Reference Sestili, Martinelli and Bravi 35 ) and act as an antioxidant in a dose-dependent response
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