Treatment should be stopped if patients do not achieve at least 5% weight loss after six months on the maximum tolerated dose
Upregulation of Antioxidant and Repair Genes: It increases the expression of genes responsible for DNA repair, antioxidant production (e.g., superoxide dismutase), and the synthesis of structural proteins like collagen and elastin
In the scientific literature, it is described as a triple agonist of the GLP-1, GIP and glucagon receptors (GCGR)
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A meta-analysis of five of these studies could not find histologic benefits with vitamin E, but there was significant heterogeneity among those studies concerning the synthesis of vitamin E that was used, the patient population, the study duration and lifestyle changes