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The reverse cholesterol transport (RCT) pathway involving high-density lipoprotein (HDL) is an important process to maintain the balance of cholesterol metabolism, and promotes the efflux of free cholesterol from macrophages ( -/- mice and found that CD36 and SRA1 levels were increased in macrophages in TMAO-treated mice compared with control mice ( via a bile salt export pump (BSEP) and finally excreted with feces ( -/- mice ( Inflammatory response Atherosclerosis is also considered a chronic inflammatory disease because the endothelial inflammatory damage is ongoing throughout atherosclerosis progression ( in vitro studies of cultured endothelial progenitor cells (EPCs) by Chou et al

The relative abundance of each gene was quantified by RPKM as defined by the following equation: Bacterial isolation, culture, and identification The gbu genes were selected as markers for isolation of key microbes involved in the conversion of BB to TMA from the human gut, and specific primers were designed (Table S5) based on the sequences of gbu gene cluster assembled from the metagenome

Within about half an hour, the researchers were able to detect glutathione depletion in a small amount of blood

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