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The synergy arises from the convergence of two independent second messenger systems cAMP/PKA from GHRHR and phospholipase C/calcium from GHS-R1a at the level of GH vesicle exocytosis
doi: 10.1210/jcem.80.9.7673411 140 FrieboesRMAntonijevicIAHeldKMurckHPollmcherTUhrMet al
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The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]
However, its most critical role in this context is how it interacts with glutathione
