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Although all three agents were prescribed within the same center, temporal changes in clinical experience, drug availability, and physician preference may have influenced treatment selection

By activating neurons that suppress appetite and blocking those that stimulate it, these medications help curb the desire to eat

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Jody Dushay, M.D., is an assistant professor of medicine at Harvard Medical School and an attending endocrinologist at Beth Israel Deaconess Medical Center

Retatrutide works as a triple receptor agonist, targeting three key hormonal pathways simultaneously: [1] [4] GLP-1 (glucagon-like peptide-1): Is thought to reduce appetite and slow gastric emptying GIP (glucose-dependent insulinotropic polypeptide): Is thought to enhance insulin secretion and may influence fat metabolism, though human evidence remains limited Glucagon receptor: Has been observed in early studies to increase energy expenditure and promote fat breakdown, though the clinical significance in humans is still being established This triple-action mechanism distinguishes retatrutide from currently approved dual or single agonists