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This comes from stability data on the FDA-approved formulation of tirzepatide (Mounjaro and Zepbound), which compounding pharmacies use as a reference point for their own formulations
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For weight loss indications, this usually means demonstrating at least a 5% reduction in total body weight
We chose DPP-4 inhibitors as comparator because they were commonly used as second or third line diabetes drugs during our study period, similar to SGLT-2 inhibitors or GLP-1 receptor agonists
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