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First, a toxic loop involving ferroptosis, -synuclein, and neuromelanin exists in the PD microenvironment, yet this study has not clarified the bidirectional regulation between ferroptosis and -synuclein oligomersspecifically, whether oligomers disrupt LIP homeostasis to trigger ferroptosis, or how lipid peroxidation products from ferroptosis accelerate protein aggregation

Its primary job is to neutralize free radicalsunstable molecules that can damage cellsand to assist in the detoxification of various compounds

2017;27(4):e23-e25.

K.TsiftsoglouA

FGF21 has originally been described as a fasting hormone that is upregulated in the liver via PPAR and partly regulates ketogenesis during starvation or KDs