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Current recommendations for individuals losing weight on GLP-1 are 1.2-1.6 grams per kilogram of body weight, or an absolute target of 80-120g per day
Moreover, by targeting inflammatory pathways such as NF-B and HIF-1, and reducing pro-inflammatory cytokines, mainly IL-6 and TNF-, these compounds protect against melanocyte loss characteristic of this disorder 150,151
Certainty of evidence was evaluated using the GRADE methodology
Factors such as your medical records, health history and current FDA recommendations will impact the decision
Effectiveness Comparison Tirzepatide (the active ingredient in Mounjaro and Zepbound) produces higher average weight loss than semaglutide in clinical trials
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